BUBONIC PLAGUE: HISTORICAL ASPECTS AND THERAPY

Efficacy of Ciprofloxacin-Gentamicin Combination Therapy in Murine Bubonic Plague

Potential benefits of combination antibiotic therapy for the treatment of plague have never been evaluated. We compared the efficacy of a ciprofloxacin (CIN) and gentamicin (GEN) combination therapy with that of each antibiotic administered alone (i) against Yersinia pestis in vitro and (ii) in a mouse model of bubonic plague in which animals were intravenously injected with antibiotics for fiv...

Further Cases of Bubonic Plague Contracted at Plague Necropsies

ed signs of suppuration on April 28th and four ounces of pus were let out by incision. "On May 2nd,symptoms of pneumonia appeared and he coughed up frothy blood. He died on May 3rd, fourteenth day from the commencement of the attack. Medical opinion was divided over this case, some holding that it was a case of ordinary septicaemia,and others that it was plague septicaemia. Taking into consider...

Sulphadiazine in the Treatment of Bubonic Plague

The value of some of the sulphanilamide derivatives in the treatment of plague has now been well recognized. In a field trial conducted at Bettiah, Bihar, in 1940, it was found that both sulphathiazole and sulphapyridine reduced the case mortality in bubonic plague to a significant extent. These results were confirmed in subsequent trials carried out at Latur in 1940 and 1941. Sulphadiazine, an...

Bubonic plague in nineteenth-century China

century (tenuously, since, as the author does not state, only the plan for this example is known and there is no evidence that the building was ever erected) and still in use in the thirteenth century for hotels-Dieu and monastic hospitals, mainly Benedictine. Though Karassava-Tsilingiri does not say so, his conclusions-if accepted-are of very great importance for the history of medical institu...

An Unusual Form of Bubonic Plague